Association Between Menstrual Irregularity and Dry Eye Disease: A Population-Based Study
Song, Jae-Yen MD, PhD*; Kim, Min-Ho MD†; Paik, ji-Sun MD, PhD‡; Kim, Hyun-Seung MD, PhD†; Na, Kyung-Sun MD, PhD†; Epidemiologic Survey Committee of the Korean Ophthalmologic Society
Purpose: To determine whether dry eye disease (DED) is associated with irregular menstruation among Korean women.
Methods: In this population-based study, we randomly selected 6502 women (19–50 year olds) from nationally representative participants in the fifth annual Korea National Health and Nutrition Examination Survey (2010–2012). Data were analyzed using logistic regression to evaluate the association between menstrual irregularity and DED, while controlling for demographic characteristics, lifestyle factors, and parity.
Results: After adjusting for the women’s demographic characteristics, age and body mass index, lifestyle factors (smoking, alcohol consumption, physical activity, and residential area), and parity, we found that menstrual irregularity was associated with an increased risk of DED (odds ratio, 1.49; 95% confidence interval, 1.02–2.17) and DED symptoms (odds ratio, 1.43; 95% confidence interval, 1.09–1.89).
Conclusions: We found a significant association between DED and menstrual irregularity.
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